Jolanta Sawicka Selected Research

Myosin Light Chains (Myosin Essential Light Chain)

1/2018	L-NAME improves doxycycline and ML-7 cardioprotection from oxidative stress.
11/2013	Matrix metalloproteinase-2 is activated during ischemia/reperfusion in a model of myocardial infarction.
9/2013	Combined subthreshold dose inhibition of myosin light chain phosphorylation and MMP-2 activity provides cardioprotection from ischaemic/reperfusion injury in isolated rat heart.
9/2012	Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia-reperfusion injury.
7/2012	Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2.
5/2011	Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.
7/2005	Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2.

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Jolanta Sawicka Research Topics

Disease

10	Ischemia 06/2021 - 07/2005
9	Reperfusion Injury 01/2014 - 05/2003
3	Hypoxia (Hypoxemia) 06/2021 - 11/2009
3	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018 - 05/2003
2	Death (Near-Death Experience) 12/2017 - 01/2016
1	Obstructive Sleep Apnea 06/2021
1	Neoplasms (Cancer) 11/2016
1	Myocardial Infarction 11/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 08/2012
1	Asphyxia (Suffocation) 12/2010
1	Heart Diseases (Heart Disease) 12/2010
1	Lung Injury 01/2010
1	Acute Lung Injury 01/2010
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2010
1	Heart Injuries 11/2009
1	Edema (Dropsy) 09/2008
1	Pathologic Processes 08/2007
1	Atherosclerosis 05/2005
1	Myocardial Stunning (Stunned Myocardium) 05/2003

Drug/Important Bio-Agent (IBA)

11	Matrix Metalloproteinase 2 (Gelatinase A)IBA 06/2021 - 05/2003
7	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2018 - 07/2005
5	Matrix Metalloproteinases (MMPs)IBA 01/2014 - 05/2003
5	Proteins (Proteins, Gene)FDA Link 08/2012 - 06/2008
4	Contractile ProteinsIBA 01/2014 - 05/2003
4	ProteomeIBA 09/2012 - 06/2008
3	Doxycycline (Periostat)FDA LinkGeneric 01/2016 - 09/2008
2	Troponin IIBA 01/2018 - 05/2003
2	Matrix Metalloproteinase InhibitorsIBA 01/2016 - 09/2008
2	Small Interfering RNA (siRNA)IBA 01/2016 - 01/2014
2	myosin light chain 2IBA 08/2012 - 12/2010
2	Adenosine Triphosphate (ATP)IBA 08/2012 - 12/2010
2	Peroxynitrous Acid (Peroxynitrite)IBA 05/2011 - 11/2009
2	Cardiac MyosinsIBA 12/2010 - 11/2009
1	Oxygen (Dioxygen)IBA 06/2021
1	Biomarkers (Surrogate Marker)IBA 06/2021
1	Lipocalin-2IBA 12/2017
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2016
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2016
1	Phosphotransferases (Kinase)IBA 09/2013
1	Myosin-Light-Chain KinaseIBA 09/2012
1	ML 7IBA 09/2012
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 08/2012
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 08/2012
1	IronIBA 05/2011
1	NitritesIBA 05/2011
1	PhenanthrolinesIBA 05/2011
1	3-nitrotyrosineIBA 05/2011
1	NitratesIBA 05/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2011
1	Y 27632IBA 12/2010
1	rho-Associated KinasesIBA 12/2010
1	Amino Acids FDA Link 11/2009
1	1,10-phenanthrolineIBA 09/2008
1	SolutionsIBA 09/2008
1	Transferrin (beta 2 Transferrin)IBA 09/2008
1	AlbuminsIBA 09/2008
1	ZincIBA 08/2007
1	EndopeptidasesIBA 08/2007
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2005
1	AMP-Activated Protein KinasesIBA 06/2004
1	Tissue Inhibitor of Metalloproteinase-4IBA 05/2003
1	ElementsIBA 05/2003

Therapy/Procedure

1	Radiotherapy 11/2016
1	Therapeutics 01/2010
1	Artificial Respiration (Mechanical Ventilation) 01/2010
1	Resuscitation 11/2009